Journal of Tissue Science and Engineering

ISSN: 2157-7552

Open Access

Ricardo A Rosselló

Department of Biochemistry, University of Puerto Rico, Medical Sciences Campus,
San Juan
Puerto Rico

  • Research Article
    Enhanced Volume of Stem Cell-Based Regenerated Tissue Achieved by Altering Microenvironment and Cell Seeding Strategies
    Author(s): Ricardo A Rosselló and David H KohnRicardo A Rosselló and David H Kohn

    Tissue engineering has emerged as a potential alternative or complementary solution to organ failure or damage. Adult stem cell based approaches can provide a powerful platform for regeneration, given these cells capacity to differentiate into multiple tissues, given the appropriate signals. However, a barrier in the development of tissue in 3D constructs is the transport limitations of nutrients and by products to the core, producing low volumes of regenerated tissue. The microenvironment in the immediate vicinity of the cells, the number of cells that adhere to the substrate and their localization may play an important role in differentiation and tissue regeneration. In this study, we aim to overcome compromised development of hard tissue using 3D cell-based tissue engineering strategies. Specifically, we quantified the effect of a biomimetic template and cell seeding techniques in .. Read More»
    DOI: 10.4172/2157-7552.S1-005

    Abstract PDF

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