Journal of Hypertension: Open Access

Po-Lei Lee

Publications

• Research Article
  Role of Beta-Adrenoceptors in Cooling-Evoked Hemodynamic Perturbations of Rats: Investigation by Spectral Analysis
  Author(s): Yia-Ping Liu, Yi-Hsien Lin, Yu-Chun Chen, Po-Lei Lee and Che-Se TungYia-Ping Liu, Yi-Hsien Lin, Yu-Chun Chen, Po-Lei Lee and Che-Se Tung
  
  Aim: Rapid immersion of a rat’s limbs into 4°C water, a model of cooling stress (CS), can elicit hemodynamic perturbations (CEHP). We have reported that CEHP is highly relevant to the sympathetic activation. This study identifies the role of β-adrenoceptors in CEHP. Method: Conscious rats were pretreated with the β-adrenoceptor blockade propranolol, (PRO)-only, or following the removal of sympathetic influences using hexamethonium (HEX) or guanethidine (GUA), and then they were subjected to a 10-min CS trial. Cardiovascular indices were monitored via an implanted telemetric device throughout the experimental course. The analyses included measurements of systolic blood pressure (SBP); heart rate (HR); cardiovascular variability (BPV; HRV); spectral coherence at very-low, low, and high frequency regions (VLF: 0.02-0.2 Hz, L.. Read More»
  DOI: 10.4172/2167-1095.1000209

  Abstract PDF