Department of Psychiatry and Neurosciences
Laval University
Canada
Guertin indicate that, following an injury to the spinal cord, spinal neuron circuits of either side of the lesion remain 'live', but 'reorganize' and undergo many changes. The intrinsic properties at the cellular level are studied, as are the types of changes 'plasticity' at the cellular and genetic organization of neuronal networks. Along with these basic research, the team of Dr. Guertin recently discovered pharmacological treatment that can potently activate locomotor neurons of the spinal cord in paraplegic mice, even in the absence of brain signals. This discovery is now being patented abroad and clinical tests in humans are planned. Through regular locomotor training induced by drugs and in paraplegic quadriplegic, this innovative treatment would prevent the development of serious health problems associated with physical inactivity suffered by these individuals, such as muscle atrophy, osteoporosis, obesity, cardiovascular problems, hormonal disorders, immune deficiencies and skin infections, lung and kidney.
Spinal cord, Spinal neuron
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