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Molecular and Genetic Medicine

ISSN: 1747-0862

Open Access

Patricio Gariglio

Centro de Investigación y de Estudios Avanzados del IPN,
Av. IPN 2508. Colonia San Pedro Zacatenco, Ciudad de México C.P. 07360
Mexico

Publications
  • Review Article
    Role of HR-HPVs E6 and E7 Oncoproteins in Cervical Carcinogenesis
    Author(s): Patricio Gariglio, Jorge Organista-Nava and Elizabeth Alvarez-RiosPatricio Gariglio, Jorge Organista-Nava and Elizabeth Alvarez-Rios

    The strategies that High Risk Human Papillomavirus (HR-HPVs) have developed in differentiating epithelial cells to reach a DNA-synthesis competent state are basically related to the overexpression of the E6 and E7 oncoproteins and the cellular regulatory pathways that are targeted by them. These are basically related to hallmarks of cancer, and include sustaining proliferative signals, the evasion of growth suppression and immune destruction, replicative immortality, inflammation, invasion, metastasis and angiogenesis, as well as genome instability, resisting cell death and deregulation of cellular energetics. In this minireview, we summarize some of the biological activities of HVP16 E6 and E7 oncoproteins in cervical carcinogenesis. From this, it is evident that cervical cancer may represent an important model to understand the different oncogenic mechanisms and processes involved n.. Read More»

    Abstract PDF

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Google Scholar citation report
Citations: 3919

Molecular and Genetic Medicine received 3919 citations as per Google Scholar report

Molecular and Genetic Medicine peer review process verified at publons

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