Does Resistin Gene Polymorphisms +299 (G>A) Participate in Insulin Resistance in Egyption Non-obese Type 2 Diabetes?
Author(s): Osama Khalil, Alsayed Alnahal, Mohamed Ghonium, Samy Fawzy, Magdy Ibrahem, Nermin Raafat and Walaa SamyOsama Khalil, Alsayed Alnahal, Mohamed Ghonium, Samy Fawzy, Magdy Ibrahem, Nermin Raafat and Walaa Samy
Background: Insulin Resistance (IR) is a condition which precedes the development of type 2 diabetes mellitus (T2DM). Resistin is a hormone secreted by adipocytes. Resistin gene (RETN) polymorphisms has been found to be associated with obesity and insulin resistance. We choose 60 patients have known type 2 diabetes mellitus against 45 healthy subjects to investigate the relationship between RETN +299 gene polymorphisms and insulin resistance, in non-obese patients with T2DM. Results: The present study revealed statistically significant increase in AA and combined GA+AA genotypes (with ODD Ratio 4.04 and 4.75 respectively), and statistically significant decrease in GG genotype in non-obese T2DM as compared to the control subjects. Also we found statistically significant increase in A allele and serum resistin in T2DM group as compared to the co.. Read More»