Journal of Clinical & Medical Genomics

Nachimuthu Senthil Kumar

Publications

• Research Article
  Mutation Profiling in Mitochondrial D-Loop Associated with Stomach Cancer and Tobacco Consumers
  Author(s): Rebecca Lalmuanpuii, Souvik Ghatak, Jeremy L Pautu, Doris Lallawmzuali, Rajendra Bose Muthukumaran and Nachimuthu Senthil KumarRebecca Lalmuanpuii, Souvik Ghatak, Jeremy L Pautu, Doris Lallawmzuali, Rajendra Bose Muthukumaran and Nachimuthu Senthil Kumar
  
  Within North East India, the people of Mizoram are mongoloid in origin and Cancer is a major disease condition among this tribal populace. A peculiar habit of consuming ‘‘tuibur’’ (tobacco smoke–infused aqueous solution) has been practiced in Mizoram. Blood and oral swab samples were collected from stomach cancer patients, tuibur consumers and healthy people. DNA was extracted followed by PCR amplification of the D-loop region of mtDNA. Restriction enzyme digestion of 1050 bp of the hyper variable control region of mtDNA was performed in order to gain an insight into the phylogenetic relationship of populace of Mizoram besides the genetic variations among tuibur consumers. The phylogram based on restriction enzyme analysis (AluI, HaeIII, MspI and KpnI) of the D-loop region subsumed within same mtDNA haplogroups and the markers r.. Read More»
  DOI: 10.4172/2472-128X.1000122

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