Journal of Molecular Biomarkers & Diagnosis

ISSN: 2155-9929

Open Access

Mohan Reddy N


  • Research Article
    Association of Adiponectin Gene Functional Polymorphisms (+45T/G and 276G/T) with Obese Breast Cancer
    Author(s): Mohan Reddy N, Kalyana Kumar CH and Kaiser JamilMohan Reddy N, Kalyana Kumar CH and Kaiser Jamil

    Adiponectin is a naturally occurring, active protein produced by white adipose tissue circulating levels of which have been associated with breast cancer risk. The ADIPOQ +45T/G and 276G/T polymorphisms are likely to play an important role in the susceptibility to breast cancer. To evaluate the prevalence of polymorphism of Adiponectin gene a case-control study was performed in 154 breast cancer patients and 142 controls in South India. We utilized PCR- RFLP based assay to evaluate the association between the +45T/G and 276G/T polymorphism of the ADIPOQ gene and breast cancer risk in a case control study. Frequencies of ADIPOQ +45T/G were 74%, 24% and 2% in the breast cancer patients and 83%, 15% and 2% in the controls, respectively. ADIPOQ +45T/G genotype showed a 1.7- fold increased risk for breast cancer and the 276G/T genotype showed a 1.6-fold increased risk for breast cancer. In.. Read More»
    DOI: 10.4172/2155-9929.1000138

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