Pulmonary & Respiratory Medicine

Mohammad Hossein Ghaffari

Publications

• Research Article
  Suppressing Effect of Dextromethorphan or Clonidine on Fentanyl- Induced Coughing: A Double- Blind, Prospective, Randomized Placebo- Controlled Study
  Author(s): Seyed Mojtaba Marashi, Mohammad Hossein Ghaffari, Raheleh Tavakkoli Moghaddam and Omid AzimaraghiSeyed Mojtaba Marashi, Mohammad Hossein Ghaffari, Raheleh Tavakkoli Moghaddam and Omid Azimaraghi
  
  Background: Various medications have been examined to reduce fentanyl-induced cough. We studied the efficacy and safety of premedication with dextromethorphan or clonidine versus placebo prior to intravenous fentanyl injection on the cough reflex. Methods and Materials: In a randomized double-blind placebo controlled trial, 360 adult patients of American Society of Anesthesiologists physical status I-II, scheduled for elective surgery under general anesthesia were randomly allocated into three groups receiving clonidine (0.2 mg tablet orally),dextromethorphan (15 mg orally), or placebo 60 minutes before induction of anesthesia. The incidence of cough was recorded for 1 minute after fentanyl injection and graded as none (0), mild (1–2), moderate (3–5), and severe (>5 cough). Seventy three (20.3.. Read More»
  DOI: 10.4172/2161-105X.1000150

  Abstract PDF