Immunochemistry & Immunopathology

Mazin Yousif Babiker Alsafi

Publications

• Research Article
  Pranlukast; An Alternative Potential Leptin Stimulator: Structure-Based Virtual Screening Study
  Author(s): Mazin Yousif Babiker Alsafi, Deyaa EldinTaha Manalla, Islam Adil Abdulrahman, Omar Hashim Ahmed and Tarig El-HadiyahMazin Yousif Babiker Alsafi, Deyaa EldinTaha Manalla, Islam Adil Abdulrahman, Omar Hashim Ahmed and Tarig El-Hadiyah
  
  Background: Leptin is secreted by adipocytes, transported into the brain and binds to its receptor in the hypothalamus, and activates JAK-STAT3, leading to increase in “anorexigenic peptides” which normally inhibit food consumption and reduce weight.Objectives: In the current study, a hybrid approach of molecular docking and virtual screening was performed, for the identification of active alternative compounds to manage obesity disorders.Methods: Screening was performed using structure-based drug design against approved FDA drugs; molecular modeling was done using AutoDockVina; only top 10 conformers’ ligands with highest and best scores were selected. In order to increase the likelihood of successful docking, in silico Virtual Screening (VS) of selected compounds were filter.. Read More»
  DOI: 10.4172/2469-9756.1000128

  Abstract PDF