Cardiovascular Diseases & Diagnosis

ISSN: 2329-9517

Open Access

Mark C. Houston

Division of Human Nutrition, Saint Thomas Medical Group, Saint Thomas Hospital,
4230 Harding Road, Suite 400, Saint Thomas Medical Plaza, Nashville, TN 37205

  • Review Article
    The Role of Mercury in Cardiovascular Disease
    Author(s): Mark C. HoustonMark C. Houston

    Mercury toxicity is highly correlated with hypertension, coronary heart disease (CHD), myocardial infarction (MI), stroke and other cardiovascular disease. Mercury has a high affinity for sulfhydryl (-SH) groups, which inactivates numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants [NAC (n-acetyl cysteine, ALA (alpha lipoic acid), GSH (glutathione)], with subsequent decreased oxidant defense and increased oxidative stress. Mercury binds to metallothionein and substitutes for zinc, copper, and other trace metals reducing the effectiveness of metalloenzymes. Mercury induces mitochondrial dysfunction with reduction in ATP, depletion of glutathione, and increased lipid peroxidation. Selenium and fish containing omega 3 fatty acids or omega 3 fatty acids supplements with DHA and EPA antagonize mercury toxicity. The overall vascular effects of mercury include incre.. Read More»

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