Journal of Clinical & Medical Genomics

Mairinger Fabian

Publications

• Short Communication
  Targeting Cancer Related Genes by Multiplex PCR Followed by High Throughput Parallel Sequencing
  Author(s): Vollbrecht Claudia, Mairinger Fabian, Schweighofer Carmen Diana, Heukamp Lukas, Merkelbach-Bruse Sabine, Büttner Reinhard and Margarete OdenthalVollbrecht Claudia, Mairinger Fabian, Schweighofer Carmen Diana, Heukamp Lukas, Merkelbach-Bruse Sabine, Büttner Reinhard and Margarete Odenthal
  
  The detection of a wide range of genomic alterations plays an important role in the diagnostics improving individual therapeutic approaches of cancer patients. Technologies that help to identify therapeutic relevant targets in tumor samples are a major factor on the way to a personalized medicine. The number of predictive and prognostic markers that influence the therapeutic outcome is continuously increasing. Therefore, parallel sequencing also named next generation sequencing (NGS), allowing the simultaneous analysis of numerous cancer related hotspots in many patients starting from a limited amount of DNA, is urgently needed to be established in cancer diagnostics. Different methods of target library preparation are commercially available and offer the opportunity to sequence tumor relevant hotspot mutations in a panel of genes. In the present study, a multiplex PCR approac.. Read More»
  DOI: 10.4172/2332-0672.1000115

  Abstract PDF