Molecular Biomarkers & Diagnosis

ISSN: 2155-9929

Open Access

Maheswari E


  • Research Article
    Protective Effect of Alpha Lipoic Acid against Phenytoin Induced Behavioral Abnormalities in Rats
    Author(s): Saraswathy GR, Maheswari E and Santhrani TSaraswathy GR, Maheswari E and Santhrani T

    Background: Long term administration of antiepileptic drug phenytoin is reported to cause behavioral abnormalities mediated via oxidative stress. The effect of an antioxidant alpha lipoic acid (ALA) against phenytoin induced behavioral abnormalities was investigated. Methods: The study was carried out in albino wistar rats. The rats were divided into five groups of six animals each. Group 1 received 0.2% carboxy methyl cellulose (CMC, p.o), group 2 received 20 mg/kg phenytoin (p.o), groups 3,4 and 5 received 50, 100 and 200 mg/kg (p.o) of ALA in 0.2% CMC, respectively 1 h prior to phenytoin for 45 days. Motor coordination, exploratory behavior, memory and spontaneous motor activity were evaluated by Rota rod, Hole board, Elevated plus maze and Actophotometer respectively. On day 45, regional brain lipid peroxidation and acetylcholineste.. Read More»
    DOI: 10.4172/2155-9929.1000241

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