Journal of Hypertension: Open Access

Ling Zhang

Publications

• Research Article
  The Association Study of PRKG1 Gene Polymorphism and Salt-Sensitive Hypertension among the Essential Hypertension in Beijing
  Author(s): Zheng Liu, Jingjing Wu, Jie Zhang, Yezhou Liu, Bin Liu, Jiapeng Lu, Yuxiang Yan and Ling ZhangZheng Liu, Jingjing Wu, Jie Zhang, Yezhou Liu, Bin Liu, Jiapeng Lu, Yuxiang Yan and Ling Zhang
  
  Background: PRKG1 plays an important role in regulating vascular smooth muscle contraction. And this gene is regarded as one of the candidate genes on salt-sensitive hypertension. The aim of this study was to investigate the effects of environmental risk factors and two SNPs and haplotypes structures of PRKG1 gene with blood salt-sensitive patients among essential hypertension. Method: Three hundred and forty-two essential hypertensive were recruited in a case-case study, a modified Sullivan’s acute salt load method was conducted to identify the salt-sensitivity and salt-resistant. Medical history and lifestyle risk factors were obtained by questionnaire, and blood and urine specimens were collected to test the biochemical indicators. We used the Sequenom Mass ARRAY Platform for genotyping of PRKG1 gene single nucleotide polymorphisms .. Read More»
  DOI: 10.4172/2167-1095.1000162

  Abstract PDF