Veterinary Science & Technology

Ling Zhang

Publications

• Research Article
  Pharmaco-Electrophysiology of Isolated Perfused Rat Heart Assessed with Flexible Microelectrode Arrays
  Author(s): Ling Zhang, Qingjun Meng, Xianhui Zhou, Yaodong Li, Yanmei Lu, Jianghua Zhang, Qiang Xing and Baopeng TangLing Zhang, Qingjun Meng, Xianhui Zhou, Yaodong Li, Yanmei Lu, Jianghua Zhang, Qiang Xing and Baopeng Tang
  
  Background: Heart slices and enzymatically dissociated cardiomyocytes are used in cardiac safety pharmacology for extracellular recording using microelectrode array (MEA). The aim of this study was to set up and validate a vitro cardiac surface mapping system for studies pharmaco-electrophysiology effects in Langendorff perfused rat hearts by flexible MEA. Materials and Methods: Hearts isolated from Sprague-Dawley (SD) male rat of either sex weighing 200-250 g were perfused by the Langendorff method with Tyrode’s solution. A cardiac surface mapping system suitable for recordings from Langendorff-perfused rat hearts using the Class III antiarrhythmic agents has been developed. In 48 Langendorff-perfused rat hearts, after obtaining baseline data, ibutilide, amiodarone or dofetilide were infused. The field potentials (FP) and heart rhythm.. Read More»
  DOI: 10.4172/2157-7579.1000470

  Abstract PDF