IR Iran
Research Article
Anti-Edema Effect of Epigallocatechin against Acute Spinal Cord Injury in Rats and its Correlation with the P38MAPK/NF-κb Signaling Pathway
Author(s): Lin Tao and Yue ZhuLin Tao and Yue Zhu
Study Design: This study investigated the outcome of epigallocatechin (EGCG) against edema after spinal cord injury (SCI).
Objective: To perform the evidence correlation of EGCG with p38MAPK\NF-κB\AQP4 signaling pathway, also explore the effect of EGCG on edema after SCI, and clarify the possible mechanism of the EGCG reducing the edema after SCI.
Summary of background data: Although some studies show that EGCG have a protective effect on nerve cells, there are few documents covering the relation between EGCG and SCI. On the basis of confirming significant inhibition of EGCG against edema after SCI, our research group intended to take the lead in further demonstrating the mechanism of anti-edema of EGCG against SCI.
Methods: 160 rats were randomly divided into sham - surgery, SCI, E.. Read More»
DOI:
10.4172/2165-7939.S4-006
Journal of Spine received 2022 citations as per Google Scholar report