Journal of Cytology & Histology

Laila A. Hummadi

Publications

• Research Article
  Adverse Effects of Soriatane on Rats Enterocytes: Light Microscopy and Ultrastructural Studies
  Author(s): Laila A. HummadiLaila A. Hummadi
  
  Soriatane (Acitretin) drug is a synthetic vitamin A analogue and the main metabolite of etretinate. It is considered to be the latest medicine prescribed to psoriasis patients. However, it is not used frequently because of its side-effect profile. Little is known about the Acitretin intestinal toxicity, so the objective of this study is evaluation of soriatane adverse events in daily practice treatment on the duodenum enterocytes of male rats. Two groups each of 10 Wistar male rats (5-6 weeks old), one of them is the treated group and the other is the control group. The drug was dissolved immediately in distilled water before administration, and given to treated rats by gastric intubation in the morning (0.2 mg/kg/day for 12 months), while the control group received only distilled water. A significant reduction in number and height of villi with increased mucosal thickness. Dam.. Read More»
  DOI: 10.4172/2157-7099.1000133

  Abstract PDF