Journal of Pediatric Neurology and Medicine

Keisuke Okada

Publications

• Case Report
  Cytokine Storm may Play a Role in the Pathogenesis of Human Parechovirus Type 3-Associated Acute Encephalopathy in Neonates: A Case Report
  Author(s): Yuichi Abe, Sanae Mchida, Kaori Sassa, Keisuke Okada and Hideo YamanouchiYuichi Abe, Sanae Mchida, Kaori Sassa, Keisuke Okada and Hideo Yamanouchi
  
  Background: Human parechovirus type 3 (HPeV3) is an important cause of acute encephalitis in the neonatal and early infantile periods. Typical HPeV3-associated acute encephalitis paradoxically shows no cerebrospinal fluid (CSF) pleocytosis despite virus detection in CSF and diffuse deep white matter involvement of the corpus callosum on magnetic resonance images (MRI). Patient: An 8-day-old full-term infant was found to have HPeV3 infection of the central nervous system (CNS), which was confirmed using diffusion-weighted MRI showing poor diffusivity in the bilateral deep white matter and the corpus callosum without CNS pleocytosis, as seen in previously reported cases. Interestingly, this patient had extremely elevated serum ferritin and urinary beta-2-microglobulin levels, which indicated a surge of the cytokines tumor necrotizing factor alph.. Read More»
  DOI: 10.4172/2472-100X.1000119

  Abstract PDF