Journal of Hypertension: Open Access

Kazumi Niinuma

Publications

• Research Article
  Cilnidipine, An L-/N-Type Calcium Channel Blocker, Changes the Circulating Angiotensin?(1-7)/Angiotensin II Ratio
  Author(s): Shizuka Aritomi, Kazumi Niinuma, Mai Kawakami, Tarou Nakamura, Tomoyuki Konda, Makoto Shiozaki and Michihiro YoshimuraShizuka Aritomi, Kazumi Niinuma, Mai Kawakami, Tarou Nakamura, Tomoyuki Konda, Makoto Shiozaki and Michihiro Yoshimura
  
  Objective:It is well known that cilnidipine, which is a L/N-type calcium channel blocker (CCB), has Angiotensin (Ang) II lowering effects that result in organ protective effects compared to L-type CCBs. However, a recent study indicated that angiotensin-converting enzyme (ACE) 2, which is expressed in the heart and kidney, metabolizes Ang II to Ang-(1-7), which is a peptide that has organ-protective effects. In this study, we compared the effects of the L-/N-type CCB cilnidipine and the L-type CCB amlodipine on plasma Ang peptides in a rat hypertensive model. Methods:Eight-week-old Sprague-Dawley rats were administered a chronic infusion of Ang II through an osmotic mini-pump, along with vehicle, cilnidipine, or amlodipine for 28 days, and the plasma renin-angiotensin-aldosterone system (RAAS) levels were examined. Results:.. Read More»
  DOI: 10.4172/2167-1095.1000102

  Abstract PDF