Journal of Tissue Science and Engineering

Juliana L Carvalho

Publications

• Research Article
  Characterization of Decellularized Heart Matrices as Biomaterials for Regular and Whole Organ Tissue Engineering and Initial In-vitro Recellularization with Ips Cells
  Author(s): Juliana L Carvalho, Pablo Herthel de Carvalho, Dawidson A Gomes and Alfredo M GoesJuliana L Carvalho, Pablo Herthel de Carvalho, Dawidson A Gomes and Alfredo M Goes
  
  Tissue engineering strategies, based on solid/porous scaffolds, suffer from several limitations, such as ineffective vascularization, poor cell distribution and organization within scaffold, in addition to low final cell density, among others. Therefore, the search for other tissue engineering approaches constitutes an active area of investigation. Decellularized matrices (DM) present major advantages compared to solid scaffolds, such as ideal chemical composition, the preservation of vascularization structure and perfect three-dimensional structure. In the present study, we aimed to characterize and investigate murine heart decellularized matrices as biomaterials for regular and whole organ tissue engineering. Heart decellularized matrices were characterized according to: 1. DNA content, through DNA quantificationo and PCR of isolated genomic DNA; 2. Histological structure, assessed .. Read More»
  

  Abstract PDF