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Review Article
Sarcoidosis: Unknown Etiology and Genetic Predisposition Provides Therapeutic Challenges
Author(s): Joseph E. Rotsinger and Wonder P. DrakeJoseph E. Rotsinger and Wonder P. Drake
Sarcoidosis is an idiopathic multisystem disorder characterized by noncaseating epithelioid granulomas predominately affecting lungs and lymph nodes, but with potential to affect any organ system. Sarcoidosis shares similarities in development to other infectious granulomatous diseases, such as berylliosis and tuberculosis; however, its elusive etiology and non-distinctive histology have provided many diagnostic challenges. Evidence of a transferrable antigen combined with a high incidence rate in the lungs has focused efforts primarily on antigens with airborne transmissibility. While Mycobacterium tuberculosis and Propioni bacterium acnes have provided strong associations to implicate each as a contributor to sarcoidosis.. Read More»
DOI:
10.4172/2161-105X.1000190
Pulmonary & Respiratory Medicine received 1690 citations as per Google Scholar report
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