Journal of Health & Medical Informatics

ISSN: 2157-7420

Open Access

Joel K Weltman

Alpert Medical School,
Providence, RI 02912

  • Research Article
    Information Entropy and Protein Secondary Structure in the ZEBOVMakona Ebola Virus Glycoprotein
    Author(s): Joel K WeltmanJoel K Weltman

    Abstract The current epidemic of Ebola virus disease (EVD) is caused by Zaire Ebola virus-Makona variant. Results are presented indicating that 88% of the information entropy (H) in the ZEBOV-Makona glycoprotein (GP1,2) was distributed to amino acids residing in random coil structures. In contrast, only 12% of the total H was due to mutations of amino acids in helical and extended sheet secondary structures. It is proposed that some of the H in random coils may represent mutational escape from host defense while the paucity of H in helical and extended sheet structures may reflect conformational constraints on mutation. By relating GP1,2 secondary structure and H in regions of GP1,2, this research helps to computationally identify potential targets for the design of anti-Ebola vaccines and drugs... Read More»
    DOI: 10.4172/2157-7420.1000207

    Abstract PDF

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