Journal of Cytology & Histology

ISSN: 2157-7099

Open Access

Jelena Stojsic

Service of Pathohistology, Clinical Center of Serbia,

  • Research Article
    Immunohistochemical Approach to the Diagnosis of Adenocarcinoma of the Lung
    Author(s): Jelena StojsicJelena Stojsic

    Introduction: Differentiation between adenocarcinoma of the lung (LADC) from the other non-small cell lung carcinoma (NSCLC) is possible by immunohistochemistry. When diagnosis of LADC is established, the rest of lung cancer tissue could be used for molecular testings, particularly EGFR analysis Aim: To evaluate 4 antibodies TTF-1, Napsin-A, Cytokeratin7 and Surfactant B in diagnosis of LADC. Materialsand Methods: Fifty small-sized samples, obtained upon bronchoscopy or transthoracic fine-needle lung biopsy, were included in this study. Diagnosis of LADC was performed after routine hematoxylin-eosin examination and TTF-1, Napsin-A, Surfactant B and Cytokeratin7 immunohistochemistry. Descriptive statistical method (%) was used in the study. Results: Cytokeratin7 was expressed in 90% (45/50), tha.. Read More»
    DOI: 10.4172/2157-7099.1000229

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