Cardiovascular Diseases & Diagnosis

ISSN: 2329-9517

Open Access

Japan Yasuchika Takeishi

Hikarigaoka, Fukushima 960-1295

  • Review Article
    Resistin Is a Novel Biomarker for a Risk of Heart Failure
    Author(s): Japan Yasuchika TakeishiJapan Yasuchika Takeishi

    Resistin is derived mainly from fat tissue in rodents, and serum levels are elevated in animal models of obesity and insulin resistance. Recent clinical studies have demonstrated that circulating resistin is associated with inflammation, coronary atherosclerosis, renal dysfunction, adverse prognosis in patients with atherothrombotic ischemic stroke and heart failure. In the population-based observational study, increased circulating levels of resistin are associated with incidence of new-onset heart failure, even after accounting for prevalent coronary heart disease, obesity, insulin resistance, and inflammation. In the elderly, incident heart failure rates (per 1000 person-years) elevate with increasing baseline resistin concentrations. In addition, resistin is strongly associated with risk for incident heart failure in Cox proportional hazard models controlling for clinical variable.. Read More»
    DOI: 10.4172/2329-9517.1000122

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