Journal of Spine

J Marc Simard

Publications

• Review Article
  The Sur1-Trpm4 Channel in Spinal Cord Injury
  Author(s): J Marc Simard, Seung Kyoon Woo, Bizhan Aarabi and Volodymyr GerzanichJ Marc Simard, Seung Kyoon Woo, Bizhan Aarabi and Volodymyr Gerzanich
  
  Spinal cord injury (SCI) is a major unsolved challenge in medicine. Impact trauma to the spinal cord shears blood vessels, causing an immediate ‘primary hemorrhage’. During the hours following trauma, the region of hemorrhage enlarges progressively, with delayed or ‘secondary hemorrhage’ adding to the primary hemorrhage, and effectively doubling its volume. The process responsible for the secondary hemorrhage that results in early expansion of the hemorrhagic lesion is termed ‘progressive hemorrhagic necrosis’ (PHN). PHN is a dynamic process of auto destruction whose molecular underpinnings are only now beginning to be elucidated. PHN results from the delayed, progressive, catastrophic failure of the structural integrity of capillaries. The resulting ‘capillary fragmentation’ is a unique, pathognomonic feature of PHN. Recent work has imp.. Read More»
  DOI: 10.4172/2165-7939.S4-002

  Abstract PDF