Journal of Spine

Huy T. Duong

Publications

• Research Article
  Peridural Fibrosis Associated with Postoperative Allodynia, but not Neurological Dysfunction in a Rodent Model
  Author(s): Gilbert Cadena, Huy T. Duong, Candace Floyd and Kee D. KimGilbert Cadena, Huy T. Duong, Candace Floyd and Kee D. Kim
  
  Failed back surgery syndrome (FBSS) is a prevalent, debilitating condition that affects the quality of life of many patients. The role of peridural fibrosis in FBSS continues to be a source of controversy. The authors report an association between peridural fibrosis and tactile allodynia, but not neurological dysfunction in a rodent cauda equine crush injury model. Methods Twenty-one rats were equally divided into three different treatment arms: 1) sham, 2) laminectomy-alone, and 3) laminectomy plus cauda equina crush injury. Tactile allodynia was tested and open field locomototor testing was completed according to a predetermined schedule. Animals were sacrificed on postoperative day 42. Histological sectioning was used to determine the degree of peridural fibrosis present in each group of animals. Results Animals who underwent greater surgical manipulation showed greater degrees of .. Read More»
  DOI: 10.4172/2165-7939.1000225

  Abstract PDF