Molecular Biomarkers & Diagnosis

ISSN: 2155-9929

Open Access

Hexige Saiyin

State Key Laboratory of Genetic Engineering, School of Life Sciences,
Shanghai, 200433
Bolivarian Rep. of Venezuela

  • Short Communication
    The Spectrum of Microvasculature Basal Microvilli in Human Solid Tumors: A Pilot Study
    Author(s): Xu Han, Wenhui Lou and Hexige SaiyinXu Han, Wenhui Lou and Hexige Saiyin

    In our pervious study, we had reported that basal microvilli with cellular trafficking ability exist in pancreatic ductal adenocarcinoma (PDAC) and murine PDAC models, which a remarkable example of how endothelial plasticity in tumor blood vessels feed tumor cells. As human solid tumors in different organs are driven by similar oncogenic mutations, basal microvilli may exist in other human solid tumors. Here we have done a small pilot study in human solid tumors to see whether other solid tumors take this approach, and surprisingly found that basal microvilli-like structure observed in human cholangiocarcinoma, metastatic nonfunctional pancreatic neuroendocrine tumor (panNET) and breast cancer, but not human hepatocellular carcinoma, glioblastoma, renal clear cell carcinoma and oral squamous cell carcinoma. Consistent with characteristics of basal microvilli in PDAC, immuno-staining r.. Read More»
    DOI: 10.4172/2155-9929.1000315

    Abstract PDF

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