Molecular Biomarkers & Diagnosis

ISSN: 2155-9929

Open Access

Haseeb Ahsan

Jamia Millia Islamia,
Okhla, New Delhi-110015

  • Short Communication
    Peroxynitrite Modified Photoadducts as Possible Pathophysiological Biomarkers: A Short Review
    Author(s): Rizwan Ahmad, Ashok Kumar Sah and Haseeb AhsanRizwan Ahmad, Ashok Kumar Sah and Haseeb Ahsan

    Peroxynitrite, a toxic product of the free radicals, NO and superoxide, has been implicated in the pathologies of central nervous system, inflammatory diseases, including multiple sclerosis. Peroxynitrite leads to sulfhydryl oxidation and lipid peroxidation as well as structural and functional alteration of proteins. Endogenous peroxynitrite has been found to mediate various effects, including DNA single-strand breakage. Peroxynitrite is a relatively longlived oxidant that may serve as an important cytotoxic agent. Its biological effects are due to its reactivity toward a large number of molecules including lipids, amino acids and nucleic acids. It is involved in tissue damage in a number of pathophysiological conditions such as neurodegenerative diseases, cardiovascular disorders. A change in the structure of DNA could either be due to radiation or interaction with free radicals. Fre.. Read More»
    DOI: 10.4172/2155-9929.1000263

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