87 Abdel-Shafy Mohamed, Hay ElZohor, 7th sector, 2nd level, Madinet Nasr, Cairo
Egypt						                            
                            
						
 Research Article
												Ameliorated Effects of Verapamil on Hepatotoxicity Induced by Ethanol and Carbon Tetrachloride 						
Author(s): Hanaa Fathy  Waer, Nomani Abdelhamid  Nomani and Eman Rizk  ElbealyHanaa Fathy  Waer, Nomani Abdelhamid  Nomani and Eman Rizk  Elbealy             
						
												
				 Background: Liver fibrosis progresses to cirrhosis in several settings for example, alcoholic hepatitis and produce hepatocellular dysfunction, which is also a risk factor for hepatocellular carcinoma. Aim: This study was designated to investigate the potential toxicity of CCl4 initiated by ethanol- as hepatotoxic agents on liver cellular structure glycogen, DNA contents and certain enzymes, and also to evaluate the preventive effect of a certain calcium ions antagonist like verapamil on carbon tetrachloride and ethyl alcohol-induced liver cellular injury in rats.
Materials and methods: Sixty healthy adult male albino rats weighing from 200-220 grams were used in this study. Animals were divided into 4 groups, each consisted of 15 rats: the first was considered the normal control, Group 2 was considered the model control which was given ethanol.. Read More»
				  
												DOI:
												 10.4172/2157-7099.1000142 
																	  
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