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Molecular and Genetic Medicine

ISSN: 1747-0862

Open Access

Gupta S


Tanzania

Publications
  • Mini Review
    New Delhi Metallo Beta Lactamase: Menace and its Challenges
    Author(s): Kashyap A, Rani Gupta, Sharma R, Verma VV, Gupta S and Pradeep GoyalKashyap A, Rani Gupta, Sharma R, Verma VV, Gupta S and Pradeep Goyal

    Clinicians have been facing an enormous challenge of treating infections caused by multiple drug resistant (MDR) pathogens since long. The latest and most alarming of such challenge is the emergence of New Delhi Metallo-β-Lactamase-type 1 (NDM-1) producing clinical isolates. NDM-1 is a metallo β-lactamase that confers resistance to all β-lactam antibiotics including carbapenems generally regarded as last resort to treat infections. NDM-1 is part of a huge conjugative plasmid blaNDM capable of rapid dissemination via horizontal gene transfer, transposition and recombination. Therefore, it has become a matter of global concern now as these pathogens have surpassed all geographical barriers and are threatening the public health all over the world. In addition to this, NDM-1 gene coexists with other resistance determinants such as other M.. Read More»
    DOI: 10.4172/1747-0862.1000299

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