Veterinary Science & Technology

Guilherme Alexandre Monteiro

Publications

• Research Article
  The Correlation of Glycogen Metabolism in Rabbit Myocardial Ischemia
  Author(s): Daniela Fantini Vale, Renato Martins da Silva, Raquel Ribeiro de Aguiar, Guilherme Alexandre Monteiro, Fernanda Antunes, Renato Abdala Karam Kalil, Carlos Jorge Logullo de Olveira and André Lacerda de Abreu OliveiraDaniela Fantini Vale, Renato Martins da Silva, Raquel Ribeiro de Aguiar, Guilherme Alexandre Monteiro, Fernanda Antunes, Renato Abdala Karam Kalil, Carlos Jorge Logullo de Olveira and André Lacerda de Abreu Oliveira
  
  Ischemia is responsible for several heart injuries, leading to functional disorders and higher mortality in animals. This process is a condition of blood circulatory arrest, leading to hypoxia and an anaerobic glycolysis. In this case, glycogen is fundamental to maintain energy homeostasis, through glycogen synthase kinase 3 (GSK3) regulations. This enzyme is usually involved in cardio protection, as well as several other biological processes. To study glycogen synthase kinase 3β (GSK3β), analyzing the involvement of this enzyme on cardiac system protection to understand its role in energetic metabolism during ischemia and reperfusion. Using the inflow occlusion (IO) application, the circulatory blood to the heart was blocked in adult New Zealand white rabbits. Parameters such hemogasometry as lactate levels were evaluated during the transoperatory period, using CG4+test str.. Read More»
  DOI: 10.4172/2157-7579.1000291

  Abstract PDF