Veterinary Science & Technology

Ganesh Kumbhar

Publications

• Research Article
  Optimization of Dosage Regimen of Gentamicin against Pasteurella multocida in Bovines: Old Drug, New Approach
  Author(s): Pritam Kaur Sidhu, Gurpreet Kaur, Ganesh Kumbhar, Balaje RM and Mohinder Partap GuptaPritam Kaur Sidhu, Gurpreet Kaur, Ganesh Kumbhar, Balaje RM and Mohinder Partap Gupta
  
  Background: Gentamicin is commonly used to treat Haemorrhagic Septicemia (HS) and other respiratory tract infections in bovines. But no data on its doses and schedules optimized for therapeutic success against P. multocida using pharmacokinetics (PK) - pharmacodynamic (PD) integration and modeling is available in farm animals. We investigated PD of gentamicin against P. multocida isolates and optimized the dosage schedules in buffalo species using novel approach of PK-PD modeling. Results: The minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of gentamicin against P. multocida in Mueller Hinton Broth (MHB) and serum were similar. The MBC:MIC ratios were 1.23 and 1.27, respectively, for MHB and calf serum.. The mutant prevention concentration (MPC) =6.. Read More»
  DOI: 10.4172/2157-7579.1000199

  Abstract PDF