Alternative & Integrative Medicine

ISSN: 2327-5162

Open Access

Ganesh Chandra Jagetia

Aizawl - 796 004

  • Research Article
    Radioprotective Potential of Nigella Sativa Extract in Swiss Albino Mice Exposed to Whole Body γ-Radiation
    Author(s): Ganesh Chandra Jagetia and Ravikiran PBGanesh Chandra Jagetia and Ravikiran PB

    The radioprotective activity of Nigella sativa extract (NSE) was ascertained by administering mice orally with 25, 50, 100, 150, 200, 400 or 500 mg/kg b. wt. of NSE, once daily for five consecutive days prior to 10 Gy γ-irradiation. One hour after the last administration of NSE on fifth day, the animals were whole body exposed to 10 Gy radiation. The exposure of animals to 10 Gy irradiation resulted in the death of all irradiated animals within 16 days post-irradiation, whereas administration of mice with different doses of NSE reduced the radiation-induced mortality and increased the animal survival significantly (p<0.05). The maximum number of survivors (60%) was observed in the group of animals treated with 150 mg/kg NSE. A further increase in the NSE dose up to 500 mg/kg did not significantly elevate the animal survival when compared to 150 mg/kg. Since maximum number of .. Read More»
    DOI: 10.4172/2327-5162.1000168

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