Journal of Cytology & Histology

Fatima N

Publications

• Short Communication
  Immunohistochemical Evidence of Pancreatic beta-cell Regeneration in streptozotocin-induced type 2 Diabetic Rats treated with Gymnema sylvestre Extract
  Author(s): Hafizur RM, Fatima N and Shaukat SHafizur RM, Fatima N and Shaukat S
  
  The effective dose Gymnema sylvestre (GS) leaves methanolic extract (400 mg/kg) was administered orally to neonatally streptozotocin-induced non-obese type 2 diabetic rats for 28 days and fasting glucose, serum insulin and β-cell function were measured after the treatment periods. Pancreatic β- and α-cells were identified by immunohistochemistry and β-cells number was evaluated by morphometric analysis. GS extract showed antidiabetic activity through improving serum insulin and β-cell function. The β-cells number was increased significantly in the GS-treated diabetic rats. The immunohistochemal data revealed presence of few newly formed insulin positive β-cells in the GS-treated diabetic islets. This is the direct immunohistochemal evidence of β-cells regeneration and/ or neoformation in pancreatic islets by GS extract. Cluster of β-cells .. Read More»
  DOI: 10.4172/2157-7099.1000342

  Abstract PDF