Immunochemistry & Immunopathology

ISSN: 2469-9756

Open Access

El-Shorbagy MS


  • Research Article

    Author(s): El-Shorbagy MS, El-Saied AH, Essa KS and Awad MMAEl-Shorbagy MS, El-Saied AH, Essa KS and Awad MMA

    Introduction: The development of rheumatoid arthritis (RA) is associated with the formation of a wide spectrum of autoantibodies, including rheumatoid factors (RFs) and anti-citrullinated protein antibodies (ACPAs). A family of autoantibodies that recognize carbamylated proteins, Anti-CarP antibodies can be detected in sera of RA patients. The aim of the present study was to evaluate the role of anticarbamylated protein antibody (Anti-CarP antibodies) in diagnosis of seronegative (Negative RF and Negative ACCP) RA patients, in monitoring the severity of inflammation and degree of associated joint damage. Methodology: Our study included 60 patients with seronegative RA (4 males and 56 females), their ages ranged between 29 and 70 years with a mean age of 48.5 ± 11.8 years, and 20 healthy controls of matched age an.. Read More»

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