Journal of Clinical & Medical Genomics

ISSN: 2472-128X

Open Access

Elesha SO


  • Research Article
    Relationship between Human Papillomavirus and Tumor Markers Expression among Women in Two Tertiary Hospitals in Bayelsa State, Nigeria
    Author(s): Oboma YI, Ngokere AA and Elesha SOOboma YI, Ngokere AA and Elesha SO

    Cervical Human Papillomavirus (HPV) infection in sub-Saharan Africa is among the highest in the world. HPV early proteins (E6 and E7) cause inhibition of p53 and Rb proteins respectively which are important for cell transformation. The HPV screening can be achieve using various methods like polymerase chain reaction, immunohistochemistry/ immunocytochemistry and Hybrid Capture 1/2. This study aimed at evaluating the effectiveness of some tumor markers in detecting cervical human Papillomavirus in HPV positive confirmed tissues by PCR. Fifty cervical tissue samples were subjected to nested polymerase chain reaction technique for the detection of HPV and immunohistochemistry method was used to localized and identify p53, p16 and Ki-67 antibodies. Result revealed 35(70%) expression for p16, 34(68%) for Ki-67 and 32(64%) for p53 marker in the tissue blocks stu.. Read More»

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