Journal of Oncology Translational Research

ISSN: 2476-2261

Open Access

Cohen M

30 Boulevard de la Cluse, 1205 Geneva

  • Research Article
    In Ovo Progression of Borderline Ovarian Tumors
    Author(s): Meynier S, Undurraga M, Tille JC, Petignat P and Cohen MMeynier S, Undurraga M, Tille JC, Petignat P and Cohen M

    Objective: Borderline ovarian tumors (BOTs) are generally considered to be non-invasive tumors with low malignancy potential. However, studies show that BOTs have the ability to progress to low-grade carcinomas and gain the potential to invade surrounding tissue and to metastasize. Here, we investigate whether a patient derived serous BOT (SBOT) could progress in low-grade serous carcinoma (LGSC) through in vitro and in vivo characterization. Methods: Ovarian cancer cell line from a SBOT, named OCAM, were isolated and characterized by PCR, migration assay and chick chorioallantoic membrane (CAM) assay. Results: OCAM cells express carcinoma characteristics and form a tumor in CAM. Moreover, OCAM cells get into membra.. Read More»
    DOI: 10.4172/2476-2261.1000109

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