Molecular and Genetic Medicine

Berrin Öztürk

Publications

• Research Article
  Allelic Frequencies of Mutations in Blood Coagulation Factor Genes(Factor V, Factor II) and Methylenetetrahydrofolate Reductase (MTHFR) in 201 Turkish Patients with Venous Thrombosis Complications
  Author(s): Nesrin Öztürk Erçelen, Berrin Öztürk, Havva Cömert, Mustafa Diken, Meral Gültomruk, Havva Coşkun and Ayberk AkatNesrin Öztürk Erçelen, Berrin Öztürk, Havva Cömert, Mustafa Diken, Meral Gültomruk, Havva Coşkun and Ayberk Akat
  
  Background and objectives: The objective of this study is to determine the prevalence of factor V Leiden (G1691A), prothrombin (G20210A) and MTHFR (C677T) gene mutations in 201 Turkish patients who were referred to our clinic with venous thrombosis complications such as deep venous thrombosis, ischemic complications, thromboembolism and coronary artery disease. Methods: After isolation of genomic DNA from peripheral blood samples, polymerase chain reaction (PCR) and restriction fragment length polymorphism techniques were used for analysis. Results: Among patients with venous thrombosis complications, allelic frequencies were 0.33, 0.17 and 0.04 for MTHFR (C677T), factor V Leiden (G1691A) and prothrombin (G20210A) mutations respectively. Conclusion: Homozygosity for the MTHFR C677T mutation and/or presence of at least one copy of the A allele of the Factor V Leiden G1691A mutation was.. Read More»
  

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