Ashley C Mays

Otolaryngology Resident, Wake Forest University School of Medicine,
Otolaryngology, Medical Center Blvd, 4^th Floor Watlington Hall, Winston Salem, NC 27857, 2528147606
Tanzania

Publications

Research Article
Gene Variability between Perineural-Positive and Perineural-Negative Squamous Cell Skin Cancers
Author(s): Ashley C Mays, Jeff Chou, Ann L Craddock, Lance Miller and J Dale Browne Ashley C Mays, Jeff Chou, Ann L Craddock, Lance Miller and J Dale Browne

Background: Recurrent cutaneous squamous cell cancer (CSCC) is associated with poor outcomes with perineural invasion reported as a frequent finding in such lesions. Given the morbidity associated with late recurrence, identifying aggressive subtypes of CSCC at the time of primary excision is all the more necessary. This project sought to identify differentially expressed genes (DEGs) between perineural invasion-positive (PP) and perineural invasion-negative (PN) CSCC. Gene-based classification models for diagnosis of perineural invasion in CSCC were also developed. Method: Forty fresh-frozen surgical specimens of CSCC with presence or absence of histopathological perineural invasion were processed for RNA isolation and hybridization to Affymetrix-U219 DNA microarrays. Raw gene expression data were normalized by Robust Multi-array Averaging .. Read More»
DOI: 10.4172/2472-128X.1000133

Abstract PDF