Journal of Cancer Clinical Trials

ISSN: 2577-0535

Open Access

Aparna Jayachandran

Gallipoli Medical Research Institute, School of Medicine,
Lower Lobby Level, Administration Building, Greenslopes Private Hospital, Newdegate Street, Greenslopes QLD 4120

  • Editorial
    Epithelial-to-Mesenchymal Transition as a Potential Target for Antineoplastic Therapies
    Author(s): Sushma R Rao and Aparna JayachandranSushma R Rao and Aparna Jayachandran

    Epithelial-to-mesenchymal transition (EMT) is a multi-step reprograming process resulting in a phenotype switch from an epithelial to a mesenchymal state. This phenotype switching of cells, long been studied for its role in development, is now emerging as a crucial process that endows tumor cells with migratory and invasive properties, enriches stem cell-like attributes, enhances drug resistance, prevents apoptosis and contribute to immunosuppression. A comprehensive understanding of EMT cellular program will enable identification and development of potential EMT-targeted antitumor therapeutic strategies. This Editorial briefly describes recent evidence of EMT as a driver of malignancy and evaluates various strategies to target EMT in cancer... Read More»

    Abstract PDF

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