Cardiovascular Diseases & Diagnosis

ISSN: 2329-9517

Open Access

Andrea MP Romani

10900 Euclid Avenue, Cleveland, OH 44106

  • Research Article
    Effect of Alcohol Administration on Mg2+ Homeostasis in H9C2 Cells
    Author(s): Huy Nguyen and Andrea MP RomaniHuy Nguyen and Andrea MP Romani

    Alcoholic cardiomyopathy represents one of the main clinical complications in chronic alcoholics. This pathology contrasts the seemingly beneficial effect of small doses of alcohol on the cardiovascular system. Studies carried out in liver cells exposed acutely or chronically to varying doses of EtOH indicate that intrahepatic alcohol metabolism results in a major loss of cellular Mg2+. To investigate whether EtOH administration also induced Mg2+ extrusion in cardiac cells, H9C2 cells were exposed to varying doses of EtOH for short- or ling-term periods of time. The results indicate that H9C2 cells exposed to EtOH doses higher than 0.1% (v/v, or 15 mM) extruded Mg2+ into the extracellular medium on a time- and dose-dependent manner. Consistent with the involvement of cyP4502E1 in metabolizing EtOH, administration of chloro-methiazole (CMZ) as an inhibitor of the cytochrome prevented E.. Read More»
    DOI: 10.4172/2329-9517.1000179

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