Six new triterpene saponins and three notable saponins were isolated from Me OH extracts of the succulent Stenocereus pruinosus. The structures of the isolated saponins were elucidated mistreatment MS, IR, and comprehensive NMR measurements. To develop medicine for treating Alzheimer’s illness (AD) on the premise of the amyloid cascade hypothesis, the isolated saponins were evaluated for inhibition of BACE1 activity and amyloid beta (Aβ) aggregation mistreatment thioflavin-T assay, associate degreed triterpenes as associate degree aglycone moiety and an alkalic product of the saponins were additionally evaluated. One glucoside, stenoside A, exhibited repressive activity associated with associated with and its degree of Aβ aggregation was forty.6% at a hundred a hundred. Cacti vary chiefly throughout South America to the southern areas of North America, regions that have 2 seasons clearly distinguishable as rainy and dry. succulent plants are divided into primarily 3 forms, referred to as dendriform cacti, columnar cacti, and circular cacti. Stenocereus pruinosus (Otto) Buxb. Belongs to columnar cacti cosmopolitan in semi-arid areas of the South East of Mexico, intensely managed in Central Mexico to collect its fruits, and typically cultivated as home garden. the peak of S. pruinosus is up to eight m, blanches are inexperienced with 5–8 ribs, and flowers ar infundibuliform 7–10 cm long growing within the blanch apexes with green-brownish external tepals and white internal tepals that ar made a pair of or three years when being planted The constituents of cacti are investigated by Djerassi and colleagues, WHO according a great deal of triterpenoid sapogenins in associate degree acid-hydrolyzed saponin-rich extract from several cacti and one in every of their works disclosed S. pruinosus contained oleanolic acid .Considering those reports, we have a tendency to had been any work triterpene sapogenins from several cacti and discovered that S. pruinosus contained erythrodiol, longispinogenin and 3β-hydroxy-11α,12α-epoxyolean-28,13β-olide additionally to oleanolic acid from product of Me OH extract of S. pruinosus . Now, we've been work triterpene saponins from cacti for many decades and according the identification of various saponins exhibiting bioactivities like anti-type I allergic reaction activity ,inhibition or promotion of animal pigment synthesis ,inhibition of amyloid β (Aβ) aggregation, and protecting effects on SH-SY5Y cells against Aβ-associated toxicity. Saponins are well-known phytochemicals that are comprised of 2 components, associate degree aglycone moiety and a sugar moiety. The activities of saponins are well studied and embody medication, anti-tumour, anti-obesity, anti-angiogenesis, anti-allergic, anti-microbial, and anti-Alzheimer’s illness (AD). Above all, our cluster found that saponins from cacti have distinctive structures that haven't been adequately investigated. Here, we have a tendency to report the isolation and structure elucidation of varied saponins together with half-dozen new compounds and three notable saponins isolated from the succulent Stenocereus pruinosus (Otto) Buxb.we have a tendency to additionally evaluated the activity of those compounds in terms of inhibition of Aβ aggregation and BACE1 activity. Our knowledge disclosed 2 notably outstanding findings. First, compounds one and 6–7 have a rare linkage of a sugar unit. Compound one features a glucopyranosyl unit that binds to the C-22 region of its aglycone, whereas half-dozen features a xylopyranosyl unit that binds to the C-3′ of glucuronic acid, and seven additionally features a xylopyranosyl unit that binds to the C-2′′′ of aldohexose binding to C-28 of its aglycone. Second, compounds 2–4 have rare triterpenes for succulent plants, longispinogenin and erythrodiol, as aglycones. These are the primary reports of isolation of such saponins from columnar succulent plants.