Journal of Pharmacognosy & Natural Products

ISSN: 2472-0992

Open Access

Volume 7, Issue 4 (2021)

Commentary Pages: 1 - 1

The Search For, and Chemistry and Mechanism of, Neurotrophic Natural Products

Kevin Fredo

Neurotrophic factors, currently termed neurotrophins, that belong to a category of polypeptidyl agents, are shown to probably be helpful for the treatment of neurodegenerative maladys like Alzheimer’s disease, as a result of endogenous neurotrophic factors (NGF, BDNF, NT3, NT4) are recognized to play vital roles within the promotion of ontogeny, differentiation, and neuroprotection throughout the event of the central system. However, high-molecular weight proteins square measure unable to cross the blood–brain barrier and square measure simply rotten by proteolytic enzyme underneath physiological conditions. To handle this issue, tiny molecules which will mimic the functions of neurotrophic factors would be promising alternatives for the treatment of neurodegenerative malady. We’ve got continuing to go looking for natural product having typical neurotrophic properties, which might cause ontogeny, enhance neurite outgrowth, and shield neuronic death exploitation 3 cellular systems (PC12, rat plant tissue neurons, and MEB5 cells). during this review, we tend to summarize the neurotrophic activities and synthesis of dimeric isocuparane-type sesquiterpenes from the nonvascular plant, class diclados, the mechanism of neurotrophic neolignans, magnolol, honokiol and their sesquiterpene derivatives, and introduce distinctive neurotrophin-mimic natural product, as well as seco-prezizaane-type sesquiterpenes from the magnoliid dicot genus species, vibsane-type diterpenes from genus Viburnum awabuki, and miscellaneous natural product with neurotrophic effects discovered by North American nation.

Commentary Pages: 1 - 1

Essential Oils of Aromatic and Medicinal Plants as Botanical Biocide for Management of Coconut Eriophyid Mite (Aceria guerreronis Keifer)

Hadiza Fadel

The eriophyid parasite (Aceria guerreronis Keifer) is an infinitesimal creature that stays under the perianth of the coconut and has been one of the genuine vermin of coconut throughout the previous thirty years in significant coconut developing nations. These little bugs total in states in the internal and external bracts and under the tepals and feed on the meristematic tissues on the nut surface. Because of bug assembly and taking care of the meristematic tissue underneath the perianth becomes chlorotic and afterward breaks. A. guererronis pervasion prompts surface scars, decreased organic product development, and untimely organic product fall. The announced yield misfortune brought about by A. guererronis was discovered to be 34% in India. In the previous few years, a few examinations have zeroed in on the expected utilization of fundamental oil details in natural control of different bug and illnesses. The fundamental oils which get more quickly corrupted into the climate than substance compounds have been read for their activity against different bug of put away items. Late examinations have exhibited the antilarval and antifeeding, postponed grown-up rise and egg mortality, arrestant and repellant activities of fundamental oils. The current examination has been expected to utilize these characteristic subordinates as an option ecofriendly intends to control the eriophyid bugs (A. guererronis Keifer), one of the genuine bugs of coconut.              

Editorial Pages: 1 - 1

Development and Validation of an Analysis Method for Pesticide Residues by Gas Chromatography‚??Tandem Mass Spectrometry in Daikenchuto

Astou Cheikh

Daikenchuto (DKT) is one in every of the foremost wide used “Kampo” in Japan as a representative of seasoner medication. as a result of DKT is formed from a natural product like food, it needs the management of pesticides; so, associate degree analysis of residual pesticides in Kampo is needed. the globe Health Organization (WHO) indicates that chemical residue analysis by the U.S. formulary (USP) is needed.

Editorial Pages: 1 - 1

Amyloid ő≤ aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus pruinosus

Arcelio Tsane

Six new triterpene saponins and three notable saponins were isolated from Me OH extracts of the succulent Stenocereus pruinosus. The structures of the isolated saponins were elucidated mistreatment MS, IR, and comprehensive NMR measurements. To develop medicine for treating Alzheimer’s illness (AD) on the premise of the amyloid cascade hypothesis, the isolated saponins were evaluated for inhibition of BACE1 activity and amyloid beta (Aβ) aggregation mistreatment thioflavin-T assay, associate degreed triterpenes as associate degree aglycone moiety and an alkalic product of the saponins were additionally evaluated. One glucoside, stenoside A, exhibited repressive activity associated with associated with and its degree of Aβ aggregation was forty.6% at a hundred a hundred. Cacti vary chiefly throughout South America to the southern areas of North America, regions that have 2 seasons clearly distinguishable as rainy and dry. succulent plants are divided into primarily 3 forms, referred to as dendriform cacti, columnar cacti, and circular cacti. Stenocereus pruinosus (Otto) Buxb. Belongs to columnar cacti cosmopolitan in semi-arid areas of the South East of Mexico, intensely managed in Central Mexico to collect its fruits, and typically cultivated as home garden. the peak of S. pruinosus is up to eight m, blanches are inexperienced with 5–8 ribs, and flowers ar infundibuliform 7–10 cm long growing within the blanch apexes with green-brownish external tepals and white internal tepals that ar made a pair of or three years when being planted The constituents of cacti are investigated by Djerassi and colleagues, WHO according a great deal of triterpenoid sapogenins in associate degree acid-hydrolyzed saponin-rich extract from several cacti and one in every of their works disclosed S. pruinosus contained oleanolic acid .Considering those reports, we have a tendency to had been any work triterpene sapogenins from several cacti and discovered that S. pruinosus contained erythrodiol, longispinogenin and 3β-hydroxy-11α,12α-epoxyolean-28,13β-olide additionally to oleanolic acid from product of Me OH extract of S. pruinosus . Now, we've been work triterpene saponins from cacti for many decades and according the identification of various saponins exhibiting bioactivities like anti-type I allergic reaction activity ,inhibition or promotion of animal pigment synthesis ,inhibition of amyloid β (Aβ) aggregation, and protecting effects on SH-SY5Y cells against Aβ-associated toxicity. Saponins are well-known phytochemicals that are comprised of 2 components, associate degree aglycone moiety and a sugar moiety. The activities of saponins are well studied and embody medication, anti-tumour, anti-obesity, anti-angiogenesis, anti-allergic, anti-microbial, and anti-Alzheimer’s illness (AD). Above all, our cluster found that saponins from cacti have distinctive structures that haven't been adequately investigated. Here, we have a tendency to report the isolation and structure elucidation of varied saponins together with half-dozen new compounds and three notable saponins isolated from the succulent Stenocereus pruinosus (Otto) Buxb.we have a tendency to additionally evaluated the activity of those compounds in terms of inhibition of Aβ aggregation and BACE1 activity. Our knowledge disclosed 2 notably outstanding findings. First, compounds one and 6–7 have a rare linkage of a sugar unit. Compound one features a glucopyranosyl unit that binds to the C-22 region of its aglycone, whereas half-dozen features a xylopyranosyl unit that binds to the C-3′ of glucuronic acid, and seven additionally features a xylopyranosyl unit that binds to the C-2′′′ of aldohexose binding to C-28 of its aglycone. Second, compounds 2–4 have rare triterpenes for succulent plants, longispinogenin and erythrodiol, as aglycones. These are the primary reports of isolation of such saponins from columnar succulent plants.

Editorial Pages: 1 - 1

Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases

Osague Ehioze

Recent analysis progress on the “second generation” sort III polyketide synthases is summarized. This category of enzymes catalyzes uncommon condensation chemistries of CoA thioesters to come up with numerous core structures of medicinally vital plant secondary metabolites, as well as the R1–C–R2 scaffold of group quinolones, curcuminoids, yet because the 8-azabicyclo octane ring of tropane alkaloids. The invention of this fascinating catalyst taxonomic category provides glorious opportunities for the manipulation of the catalyst reactions to expand the availability of natural and unnatural molecules for future drug development. The type III polyketide synthase (PKS) taxonomic category enzymes generate unbelievably numerous core structures of medicinally vital plant secondary metabolites, as well as flavonoids, stilbenes, chromones, pyrones, phloroglucinols, resorcinols, xanthones, acridones, and quinolones . For instance, chalcone synthase (CHS) and stilbene synthase (STS) are plant-specific typical sort III PKSs that settle for p-coumaroyl-CoA because the starter substrate to catalyse 3 sequent condensations with malonyl-CoA to come up with naringenin chalcone and resveratrol, severally.

arrow_upward arrow_upward