Journal of General Practice

New biomarkers for specific health conditions have been discovered as a result of the proliferation of metabolic research over time. One of the most recently and thoroughly developed bio fluids in the human body, saliva can be used as an informative substance for metabolomic profiling. The purpose of this review is to look at what is known about the human salivary metabolome, how it changes as a result of physiological, environmental and other factors, as well as the limitations and problems that have been found in the most recent research, with an emphasis on pre-analytical and analytical workflows. Additionally, we will investigate the possibility of using the saliva metabolomics profile as a biomarker for oral diseases like periodontitis and oral cancer.

To examine how the colour stability of various nanoparticle-modified resin-based composite (RBC) materials is affected by beverages (coffee, tea, Cola-Cola and mineral water). The 70 beverage specimens were made from RBCs that had been light-cured and divided into four groups based on NPs: one unaltered control (N0); and three ZrO2 (Zr), TiO2 (Ti) and SiO2 (Si) experimental groups. NP concentrations were used to further divide each experimental group into two subgroups: 3 and 7 weight percents. Before and after six months of immersion, the colour change (E) was measured with a spectrophotometer. One-way ANOVA, Bonferroni’s post-hoc test and E value conversion to National Bureau of Standards (NBS) units were used to compare and analyse the data. After being immersed in the beverages, the light-cured RBCs that had been modified with ZrO2, TiO2 and SiO2 had smaller colour changes than the unmodified group.

Primary healthcare is the cornerstone of any healthcare system. It is the first point of contact between patients and the healthcare system, and it is where most of the health promotion, disease prevention, and early detection of health problems occur. Hospitals, on the other hand, are usually associated with providing secondary or tertiary healthcare services, such as specialized medical care and advanced diagnostic and treatment procedures. However, hospitals also have a significant contribution to the improvement of primary healthcare. In this article, we will discuss the role of hospitals in primary healthcare and how they can contribute to improving the quality of primary healthcare services.

Challenges in the placement of dental implants and managing them in general dentistry Dental implants have become a popular and effective method of tooth replacement, with success rates of up to 98%. However, the placement and management of dental implants in general dentistry can present several challenges, including patient selection, implant placement, implant maintenance, and complications. In this article, we will explore these challenges and strategies for managing them in general dentistry.

Vaccination is one of the most effective public health interventions, preventing millions of deaths each year from infectious diseases. Vaccines are a critical component of primary healthcare, and they play a crucial role in achieving universal health coverage. Universal health coverage (UHC) aims to ensure that all people have access to quality healthcare services, including preventive, curative, and rehabilitative services, without financial hardship. In this article, we will discuss the importance of vaccination campaigns in achieving universal health coverage and how vaccination campaigns can contribute to the attainment of UHC.