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Journal of Bioanalysis & Biomedicine

ISSN: 1948-593X

Open Access

Volume 12, Issue 3 (2020)

Review Pages: 1 - 6

A Review on LBA and LC-MS Platforms for Supporting Large Molecule Pharmacokinetics Bioanalysis

Linglong Zou*, Xiaolong Zhang, Zhaoyang Zhang, Weiping Shao and Zhongping Lin

DOI: 10.37421/1948-593X.2020.12.227

Over the past ten years, the global market for large molecule therapeutics has rapidly grown for the treatment of a variety of diseases. LBA and LC-MS are two platforms widely used in pharmacokinetic bioanalysis. In this review, we compare LBA and LC-MS and summarize their strengths and limitations. Strategies for platform selection are provided according to the study purpose, study phase, analyte types, assay requirements and other factors.

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Citations: 3099

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