Epilepsy Journal

This study investigates the intricate relationship between neuroanatomy, neurophysiology, and turning performance in individuals diagnosed with Multiple Sclerosis (MS). Multiple Sclerosis is a complex neurological disorder characterized by demyelination and neuroinflammation, leading to a wide range of motor and sensory impairments. Understanding how specific neuroanatomical and neurophysiological factors influence turning ability is crucial for optimizing rehabilitation strategies and enhancing the quality of life for individuals with MS. Through advanced imaging techniques, neurophysiological assessments, and kinematic analyses, this research aims to uncover the underlying mechanisms that contribute to turning deficits in MS patients. The findings from this study will provide valuable insights into personalized treatment approaches and interventions for improving mobility and functional independence in this population.

Deep-sea oceanauts operate in challenging and high-stress environments where cognitive workload plays a pivotal role in task performance and safety. This study aims to analyze mental workload among deep-sea oceanauts during driving operation tasks using Electroencephalogram (EEG) data. We collected EEG data from oceanauts engaged in simulated driving tasks in a submersible vehicle, assessing cognitive workload through neural markers. Our findings reveal distinct patterns of mental workload across different phases of the driving operation, shedding light on the cognitive demands and potential stressors faced by oceanauts in these conditions. This research contributes to enhancing safety and performance optimization for deep-sea missions.

This study aimed to isolate and characterize bacteriocin-producing Lactic Acid Bacteria (LAB) from the intestinal microbiota of Gilthead Seabream (Sparus aurata) and Whiting Fish (Merlangius merlangus). LAB are known for their potential as probiotics and natural preservatives due to their ability to produce antimicrobial peptides known as bacteriocins. In this research, LAB strains were isolated, identified, and their bacteriocin production assessed. Additionally, the inhibitory spectrum and safety profiles of the bacteriocins were investigated. The results provide valuable insights into the potential use of LAB-derived bacteriocins in aquaculture and food preservation.

This study presents advancements in the functionality and characterization of an electrophysiological mapping electrode probe equipped with directional carbonic macrocontacts. The probe's enhanced design and improved performance make it a valuable tool for precise neural recording and mapping applications. We discuss the methodology employed for the functional enhancements, provide a detailed characterization of the probe's capabilities, and highlight its potential contributions to neuroscientific research.

This study investigates the immediate effects of a single session of OnabotulinumtoxinA therapy on sleep quality and psychological measures in patients suffering from chronic migraine. Chronic migraine is a debilitating condition characterized by frequent and severe headache attacks, often leading to disrupted sleep patterns and adverse psychological well-being. While OnabotulinumtoxinA has shown efficacy in reducing migraine frequency and severity, its impact on sleep quality and psychological parameters remains underexplored. In this preliminary study, a cohort of chronic migraine patients received a single OnabotulinumtoxinA therapy session. Sleep quality was assessed using validated sleep questionnaires, and psychological measures, including anxiety and depression levels, were evaluated through standardized psychological assessments. Baseline measures were compared with post-treatment data to determine the immediate impact of OnabotulinumtoxinA on sleep quality and psychological well-being. Preliminary findings indicate a significant improvement in sleep quality within hours of OnabotulinumtoxinA administration, suggesting its potential role in alleviating sleep disturbances associated with chronic migraine. Furthermore, there was a notable reduction in anxiety and depression scores, highlighting the therapeutic potential of OnabotulinumtoxinA in addressing the psychological burden of chronic migraine patients. These preliminary findings suggest that a single OnabotulinumtoxinA therapy session may have a rapid and positive impact on sleep quality and psychological well-being in chronic migraine patients. Further research is warranted to confirm and expand upon these initial observations and explore the long-term effects of OnabotulinumtoxinA therapy on these parameters.

This study investigates the intricate relationship between brain dopamine-clock interactions and their impact on cardiometabolic physiology, with a particular focus on elucidating the mechanisms underlying the observed cardioprotective effects of circadian-timed Bromocriptine-QR therapy in individuals with Type 2 Diabetes. The circadian rhythm plays a pivotal role in regulating various physiological processes, including metabolism and cardiovascular health. Through a comprehensive analysis of the interplay between brain dopamine pathways and the circadian clock, we aim to provide insights into the therapeutic potential of timing medication administration to align with the body's natural rhythms. Our findings shed light on the intricate web of molecular and physiological mechanisms governing this interaction, offering new perspectives for optimizing treatment strategies in Type 2 Diabetes management while promoting cardiovascular health.

This study presents a novel Mobile Electroencephalography (EEG) system and evaluates its performance in comparison to conventional clinical EEG. The mobile EEG system offers an innovative approach to EEG monitoring, providing potential benefits in terms of portability and ease of use. In this research, we conducted a comprehensive assessment of the mobile EEG system's quality, examining its accuracy and reliability when compared to traditional clinical EEG recordings. Our findings highlight the potential utility of the mobile EEG system as a valuable tool for noninvasive brain activity monitoring in various clinical and research settings.

This study explores the neurophysiological implications of motor threshold variability observed during transcranial magnetic stimulation treatment for depression. TMS is a promising therapeutic approach, but its effectiveness may be influenced by variations in motor threshold across individuals. We investigated the potential impact of these threshold fluctuations on treatment outcomes, shedding light on the neurophysiological mechanisms at play. Our findings provide insights into the optimization of TMS protocols for more effective depression management.

This study delves into the dynamic aspects of human neurophysiological responses during an authentic olfactory experience in a naturalistic setting. The research explores the temporal dimensions of neurophysiological activities as individuals engage with ecological odors. Through the use of advanced monitoring techniques, we examine how these responses evolve over time, shedding light on the intricate interplay between the olfactory system and human cognition in real-world scenarios. This investigation contributes valuable insights into the temporal dynamics of sensory perception and its implications for our understanding of human brain function in ecologically relevant contexts.

This study explores the potential utility of nutritional interventions in the management of chronic mild traumatic brain injury, concussion, and sportsrelated concussion. We delve into the emerging evidence suggesting that nutrition may play a crucial role in the recovery and long-term outcomes of individuals affected by these conditions. The review encompasses various aspects of nutrition, including dietary components, supplements, and dietary patterns, and their impact on brain health, cognitive function, and symptom management in the chronic phase of mTBI and concussion. We analyze recent research findings, highlighting the need for further investigations to elucidate the specific mechanisms underlying the observed effects. The insights presented in this review underscore the promising avenues for incorporating nutrition into the comprehensive care strategies for individuals with chronic mTBI, concussion, and SRC.