Clinical and Medical Case Reports

Epidemiological data from the COVID-19 pandemic shows increased severity and mortality among males compared with females. Several studies offer evidence that this disparity may be, in part, due to sex hormone biases contributing to different outcomes in SARS-CoV-2, suggesting hormone therapy as a potential combination treatment alongside antivirals in COVID-19. This review explores the potential mechanisms by which estrogen and androgen have distinct impacts on the development of COVID-19.

RCTs, or randomized controlled trials, are regarded as the highest quality level for addressing evidence gaps in Q3 medications. In any case, RCTs are not always plausible because they can take a long time to complete and be prohibitively expensive, or they may require the examination of human comparator arms to find appropriate proof. In fact, even when RCTs are plausible, they may not provide all of the important information needed to guide clinical decisions or wellness strategies. In such a situation, observational studies and meta-investigations, two notable techniques with relative viability, might be able to fill in the gaps in the evidence. structure to bring together the best Q5 evidence from a variety of sources and highlight "ideal" choices under a variety of conditions.