Divya Kajaria and Tanuja Nesari
The article explores the concept of developing pathogenesis specific medicines for the management of SARS-CoV-2. This is high time to shift the paradigm from pathogen specific (vaccine) treatment to pathogenesis specific treatment for the permanent solution of such pandemics. The article gives an empherical outlook about the fact that immune system gives a sequential response to any invading matter and augmenting the immune response at first step prevents the development of disease. During evolution, immune responses for invading proteins are specified and categorize based on their lethality. Those proteins which are encounter during envenomation are recognized by the immune cell as toxin. The core concept that the human body has stored memory for venomous protein response conclude possibility that envelop proteins of coronavirus belongs
to venom group of protein. The article introduces the concept that human immune system recognizes novel coronavirus envelop protein and nucleocapsid as toxin and therefore giving hyper-immune response like cytokines storm. Potential of this concept and its utility in the management of COVID-19 is discussed under two headings (1) Use of anti-toxin herbs and (2) Detoxification therapies. Herbs described as Anti-toxin can be extracted and use as natural source of neutralizing antibodies for passive immunity. The article gives the details of natural ways described in Ayurveda for creating HERD immunity and also explains the concept of cosmic immunity, its role in the outbreak of epidemics and utility in prevention of spread of disease. Novel concept of neuro-endocrine-immune response (using thought modulation as immune-stimulant) and the possibility of pseudo-illness due to infodemic is also converse in the article. The Ayurvedic measures described in the article can be used for asymptomatic patients, quarantine people and high risk health workers. These are simple, safe measures that can be easily followed to maintain physical as well as mental health during pandemic.
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