Journal of Bioanalysis & Biomedicine

ISSN: 1948-593X

Open Access

Ultra-Small Superparamagnetic Iron Oxide Nanoparticles Made to Order


Benyettou F, Milosevic I, Olsen JC, Motte L and Trabolsi A

A fast, efficient and green microwave-assisted synthesis of ultra-small, superparamagnetic iron oxide nanoparticles is reported. By controlling the temperature and heating mode of a polyol reduction using triethylene glycol (TREG) as a green, high-boiling solvent, ultra-small nanoparticles (2-4 nm) exhibiting robust superparamagnetic behavior were obtained. The sizes of the nanoparticles were determined by TEM and DLS measurements. Using a ligand exchange process, the TREG molecules on the surface of the smallest nanoparticles (2 nm) were successfully replaced with Alendronate, an anti-cancer drug molecule, effectively transforming the nanoparticles into a potential theranostic agent.


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