..

Journal of AIDS & Clinical Research

ISSN: 2155-6113

Open Access

Tolerance and Durability of Abacavir/Lamivudine (Abc/3tc) Containing Regimens: Results from a large French Prospective Cohort

Abstract

L. Cuzin, C. Allavena, L. Finkielsztejn, H. Melliez, P. Pugliese, I. Poizot-Martin, C. Duvivier, L. Levy-Bachelot and S. Abel

Background: Abacavir is considered as a potent and well tolerated drug but recent controversial data have raised questions concerning cardiovascular tolerability and virological efficacy in antiretroviral initial regimen with abacavir/lamivudine (ABC/3TC). Methods: Patients were selected from the Dat’AIDS french prospective cohort if they were prescribed a regimen containing ABC/3TC free or fixed dose combination for the first time between 01/01/2004 and 31/12/2007 before HLA screening recommendation or routine usage. All causes of treatment discontinuation were recorded, as well as immuno-virological and clinical data during follow-up. Results: Among the 1704 patients included in the study (male 69%, mean age 43 years) 407 (24%) were antiretroviral naïve, 696 (41%) had viral load (VL) below detection on ARV treatment (switch), and 601 (35%) were on treatment with detectable VL (failure) at time of ABC/3TC initiation. Overall 565 patients (33%) discontinued ABC/3TC combination during follow-up, among them 26% have used ABC in the next regimen. Reasons for discontinuation were intolerance in 14% of the cases - including suspected hypersensitivity (HSR) in 7% of the overall population - treatment failure in 20%, and other causes in 39%. The median time to treatment discontinuation was 52 months for the overall population. After 2 years, the probability of receiving ABC/3TC was at 62%, 77%, and 60% respectively for the defined groups. Finally, the VL on treatment was below detection for 86%, 90%, and 71%, respectively. Conclusion: In this population ABC/3TC containing regimens were maintained with virological success for more than 2 years. Tolerance issues including HSR were the main reason for early discontinuation.

PDF

Share this article

Information

Copyright: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To cite this article:


Received Date: Jan 01, 1970
Accepted Date: Jan 01, 1970
Published Date: Jan 01, 1970

Recommended Conferences

Infectious Diseases and Control

New York, USA

Clinical Research & Clinical Trials

New York, USA
 
arrow_upward arrow_upward