Multiple Endocrine Neoplasia type 1 is a hereditary syndrome, with an autosomal dominant transmission, characterized by hyperplasia/ tumours in endocrine organs
(parathyroids, pituitary, gastro-intestinal system). The gene involved is MEN1 gene on chromosome 11q13 which encodes menin, an oncosuppressive nuclear protein
according to Knudson “two hit” hypothesis. Expression of menin and its inactivation in the thyroid gland have long been debated.
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