Medicinal Chemistry

ISSN: 2161-0444

Open Access

Synthesis of New Derivatives of Thieno[2,3-d]pyrimidin-4(3H)-one and their Antimicrobial Activity


Virupakshi Prabhakar, Gummadi Durgaprasad, Kondra Sudhakar Babu and SVN Sivananda Lahari

A series of new thieno[2,3-d]pyrimidin-4(3H)-one derivatives were synthesized. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral data. All the newly synthesized thieno[2,3-d]pyrimidin-4(3H)-one derivatives were screened for antibacterial activity against Staphylococcus aureus, Bacillus subtilis (gram positive bacteria), Escherichia coli, Pseudomonas aeruginosa (gram negative bacteria) and antifungal activity was carried out against Candida albicans and Aspergillus niger.


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